The science behind long, happy and healthy life is continuously emerging. The maximum lifespan of human being is about 120 years. How to increase that? How to add more life into those years? How can we preserve our youth? What cause aging? Can human bodies become immortal? These are the most fundamental questions in biology. Aging is almost universal, but the causes of aging are complex. The rate of aging also differs from person to person. Scientific evidence suggests that proper diet, regular exercise, regular learning and calorie restriction, during middle age and beyond is enormously effective to promote health and disease free life. Through discipline life, it is possible to make the rejuvenation and extend lifespan and possible to achieve stop senescence, reverse aging or at least significantly delay it.