Scientists observed that Sirtuin foods or sirtfoods have enormous health benefits. These foods increase longevity and quality of life. Recent research demonstrated that caloric restriction along with “sirtfoods” is the elixir of long life. Researchers are in search of sirtuin activator supplements. However, there many natural foods, which can naturally and easily activate the sirtuins. In this article, we discussed top ten natural sirtun activating foods.